Evaluation of medical prescriptions containing associations with antidepressants in a manipulation pharmacy

Resumo

(a) Objectives: to determine and evaluate the profile of prescription drugs to this pathology, regarding the risk-benefit inherent in these given the range of therapeutic options and lack of specific treatment. b) Material and Methods: was evaluated the profile of prescriptions to migraine treatment dispensed in a manipulation pharmacy from Teresina, Piauí, in the period from January 2 to June 2, 2012. (c) Results: 121 prescriptions were evaluated and all were based on prophylactic measures, not in suspension of crises. Of these, 56.51% contained nortriptyline (from 5 to 40 mg), being the association with flunarizine and atenolol the most frequent. 36,36%  contained amitriptyline (10 to 75mg) and the association with beta-blockers (propranolol or atenolol) the most frequent. Finally, because of flunarizine influence, this was also evaluated, represented by 7.43% of the prescriptions. Although unusual, was noteworthy the associations with Ginkgo biloba and vitamin B6, whose therapeutic evidence has not yet been fully elucidated. (d) Conclusions: there is a great representativity of prophylactic drugs in prescriptions from a manipulation pharmacy from Teresina, Piauí, with the tricyclic antidepressants, amitriptyline and nortriptyline, followed by the calcium channel blocker, flunarizine, the first-line drugs in the choice of local prescribers.