This might be brought on by genetic heart condition, enlarging of the valve's closure flaps or post-inflammatory changes, such as those related to rheumatic heart problem. In some cases individuals who have problems with the valve that blood flows through as it leaves the heart have actually an enhanced threat of thoracic aortic aneurysm. This is primarily true for individuals that were born with an aortic shutoff that has just 2 flaps instead of 3.

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